Thomas Cook, the world's oldest travel firm, is cutting 2,500 British jobs and closing 195 of its high street travel agencies.
Peter Fankhauser, Thomas Cook's Europe and UK chief executive, said it was "never easy" to make job cuts but insisted the company had to make sure its administrative costs were "as low as possible".
The company, which has already cut more than 1,100 jobs over the past year, will shed up to 1,600 jobs in its high street shops with the remainder coming from administrative positions.
Jobs at its head offices in Peterborough and Preston are most at risk, while its Accrington office will be shut.
The new jobs cuts represent more than 15% of Thomas Cook's 15,500 staff. Having recently shut 149 stores, Thomas Cook will be left with 874 travel agencies across the UK and Northern Ireland.
Many of the branches being closed are Co-operative Travel stores, which Thomas Cook's previous boss Manny Fontenla-Novoa bought just two year ago.